Concept of Hierarchical Biodegradable Anticancer Nanoagent Based on Layered Hydroxide

AA Tsukanov, PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS WITH HIERARCHICAL STRUCTURE FOR NEW TECHNOLOGIES AND RELIABLE STRUCTURES 2019, 2167, 020370 (2019).

DOI: 10.1063/1.5132237

Modern anticancer therapy requires maximization of negative impact on cancerous cells in same time with minimization of any adverse effects to normal cells, that is why targeted delivery and drug release system is strictly necessary as well as usage of biocompatible components in theranostics nano-agent. Naturally occurred layered double hydroxides (LDH) being biocompatible and low or null toxic form stable host-guest nanohybrids with almost any polar and anionic compounds. Structure and composition of LDHs provide them to be functionalized by wide range of chemical ligands, including folic acid, polypeptides, aptamers and other cancer cell receptors binding units. Using the steered molecular dynamics as well as previously published data, the ion exchange order for LDH was estimated. The obtained results show the possibility of targeted delivery and massive intracellular chlorine release, governed by competitive ion exchange in the cellular plasma medium. Depending on the dose, such an action can lead to both the fatal dysregulation of the ionic balance of cell and the strong adsorption of vital biomolecules and bio-ions from intracellular liquids. After the death of the cell the released chlorine ions have no harmful effect, being the most common anion of the extracellular environment. Biocompatible and biodegradable Mg/Fe(III)-based hydroxide can be further completely utilized by the organism without an adverse effect as well.

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