Hydrophobic immiscibility controls self-sorting or co-assembly of peptide amphiphiles

R Wakabayashi and R Imatani and M Katsuya and Y Higuchi and H Noguchi and N Kamiya and M Goto, CHEMICAL COMMUNICATIONS, 58, 585-588 (2022).

DOI: 10.1039/d1cc05560g

Pairs of peptide amphiphiles with immiscible hydrophobic tails were synthesized and their assembly formation was investigated. These pairs formed self-sorting supramolecular fibres using a standard heating- cooling protocol, while one pair with longer hydrophobic tails formed a co-assembly when an additional heating process was applied.

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