Stoichiometry Controls the Dynamics of Liquid Condensates of Associative Proteins

P Ronceray and YJ Zhang and XC Liu and NS Wingreen, PHYSICAL REVIEW LETTERS, 128, 038102 (2022).

DOI: 10.1103/PhysRevLett.128.038102

Multivalent associative proteins with strong complementary interactions play a crucial role in phase separation of intracellular liquid condensates. We study the internal dynamics of such "bond-network" condensates comprising two complementary proteins via scaling analysis and molecular dynamics. We find that when stoichiometry is balanced, relaxation slows down dramatically due to a scarcity of alternative binding partners following bond breakage. This microscopic slow-down strongly affects the bulk diffusivity, viscosity, and mixing, which provides a means to experimentally test this prediction.

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