Bioinspired Polyethylene Glycol Coatings for Reduced Nanoparticle- Protein Interactions

J Toro-Mendoza and L Maio and M Gallego and F Otto and F Schulz and WJ Parak and C Sanchez-Cano and I Coluzza, ACS NANO, 17, 955-965 (2023).

DOI: 10.1021/acsnano.2c05682

Nanoparticles (NPs) and other engineered nano -materials have great potential as nanodrugs or nanomedical devices for biomedical applications. However, the adsorption of proteins in blood circulation or similar physiological fluids can significantly alter the surface properties and therapeutic response induced by most nanomaterials. For example, interaction with proteins can change the bloodstream circulation time and availability of therapeutic NPs or hinder the accumulation in their desired target organs. Proteins can also trigger or prevent agglomeration. By combining exper-imental and computational approaches, we have developed NPs carrying polyethylene glycol (PEG) polymeric coatings that mimic the surface charge distribution of proteins typically found in blood, which are known to show low aggregation under normal blood conditions. Here, we show that NPs with coatings based on apoferritin or human serum albumin display better antifouling properties and weaker protein interaction compared to similar NPs carrying conventional PEG polymeric coatings.

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