Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial

L Russo and A Gautieri and M Raspanti and F Taraballi and F Nicotra and S Vesentini and L Cipolla, CARBOHYDRATE RESEARCH, 389, 12-17 (2014).

DOI: 10.1016/j.carres.2013.11.008

Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition. (C) 2013 Elsevier Ltd. All rights reserved.

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